Growth Factors Released from Gelatin Hydrogel Microspheres Increase New Neurons in the Adult Mouse Brain
Figure 3
Effects of HGF-containing gelatin hydrogel on the number of new neurons migrating in the ischemic striatum after middle cerebral artery occlusion. (a) Experimental design. (b) A coronal brain section showing DCX+ new neurons in the SVZ (green) and gelatin hydrogel that was injected into the striatum. (c) Coronal sections stained for DCX (green) from brains that received a PBS or HGF injection with ( animals for each group) or without ( animals for each group) gelatin hydrogel. (d) Quantification of the number of DCX+ cells separated by at least 50 μm from the SVZ in the ipsilateral striatum. (e) Summary of the results. HGF administered as HGF-containing gelatin hydrogel microspheres significantly increased the number of new neurons. Scale bars: 200 μm (b and c). *.
