Bilateral Transplantation of Allogenic Adult Human Bone Marrow-Derived Mesenchymal Stem Cells into the Subventricular Zone of Parkinson’s Disease: A Pilot Clinical Study
Table 1
Shows the details of the PD patients and PD plus patients recruited for the study. It also provides the subjective improvements reported by the patient/caregivers after stem cell transplantation. It is to be noted that all patients have mentioned improvement in similar aspects of PD including reduction in tremors, stiffness of limbs and clearing of speech. However, for PD, plus there are no improvements noted.
Sr. no.
Age/ sex
Duration of disease (years)-PD/PD+
Date of SCT
Type of stem cells injected
Dose administered
ROA
Autologous/ allogenic
No. of injections
UPDRS score baseline off/on
12th month off/on
Comments by caregivers/patient
1
68/M
15-PD
Feb-10
BMMSCs
2 million
IC
Allogenic
1
154/127
128/127
NA
2
37/M
5-PD
Mar-10
BMMSCs
2 million
IC
Allogenic
1
79/47
52/50
(1) Following stem cell injection his rigidity had reduced and speech had improved
3
65/M
5-PD
Mar-10
BMMSCs
2 million
IC
Allogenic
1
94/58
28/22
(1) Able to do his routine activities without much difficulty (2) Stiffness and tremors are very minimal (3) Able to walk for longer distances
4
49/M
10-PD
Dec-10
BMMSCs
2 million
IC
Allogenic
1
112/98
Lost to follow up
(1) Patient is more independent in his daily activities (2) Speech is clearer (3) Rigidity and stiffness has reduced
5
54/F
10-PD
Feb-11
BMMSCs
4 million
IC
Allogenic
1
105/72
90/68
After therapy the patient and relatives have noticed that there was a decrease in involuntary movements
6
48/M
11-PD
Feb-11
BMMSCs
2 million
IC + IV
Allogenic
1
43/32
40/28
NA
7
56/M
5-PD
Mar-11
BMMSCs
2 million
IC
Allogenic
1
NA
NA
NA
8
60/M
5-PD
Feb-11
BMMSCs
2 million
Allogenic
1
44/38
19/12
(1) After therapy, he has notice d that the tremors have reduced (2) Walking difficulty has also reduced and (3) He is able to write better now
9
65/F
10-PD +
Mar-10
BMMSCs
3 million
IC
Allogenic
1
44/20
NA
(1) Speed of walking has increased (2) Slurred speech has improved (3) Swallowing is better (4) Slight Improvement in handwriting
10
66/M
7-PD+
Jul-10
BMMSCs
2 million
IC
Allogenic
1
62/62
NA
According to the family, the symptoms have worsened since a few months
11
69/M
3-PD+
Jan-11
BMMSCs
2 million
IC + IV
Allogenic
1
NA
NA
(1) 6 months after therapy, the patient and his relatives have noticed improvement in his rigidity and movements (2) There is also improvement in his speech
12
69/F
7-PD+
4-Nov-10
BMMSCs
2 million
IC
Allogenic
1
150/153
140/133
(1) At present her involuntary movements have reduced (2) She has difficulty in swallowing and stiffness in her neck has increased
