Modelling Improvements in Cell Yield of Banked Umbilical Cord Blood and the Impact on Availability of Donor Units for Transplantation into Adults

Table 2

Mixed effects model on the impact of increasing the fraction of cells surviving storage and thawing compared to standard yields and the impact of HLA compatibility on the number of available donor units (least square means reported).

	Available donor units for patient weight
	50 Kg	70 kg	90 kg
Percentage of cells surviving^a
Standard	21.3	5.1	1.3
110% (𝑃 versus standard)	29.0 (0.33)	7.6 (0.38)	1.9 (0.50)
120% (𝑃 versus standard)	37.0 (0.047)	10.5 (0.061)	3.0 (0.068)
130% (𝑃 versus standard)	47.1 (0.002)	14.3 (0.002)	4.7 (0.0005)
Degree of HLA-match^b
6/6 HLA matched	4.8	3.0	1.8
5/6 (𝑃 versus 6/6)	56.6 (0.016)	18.6 (<0.0001)	5.2 (<0.0001)
4/6 (𝑃 versus 6/6)	39.4 (<0.0001)	6.5 (0.17)	1.3 (0.58)
4/6 (𝑃 versus 5/6)	39.4 (<0.0001)	6.5 (<0.0001)	1.3 (<0.0001)

^a𝑃 values for mixed effects model considering increases in yield of cells surviving storage and thawing (𝑃=0.011 for patient weight of 50 kg, 0.014 for 70 kg, and 0.003 for 90 kg).
^b𝑃 values for mixed effects model considering degree of HLA match (𝑃<0.0001 for patient weight of 50 kg, 70 kg, and 90 kg).