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Stem Cells International
Volume 2013 (2013), Article ID 132642, 8 pages
http://dx.doi.org/10.1155/2013/132642
Review Article

Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair

Department of Stem Cell Disorders, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan

Received 5 October 2012; Accepted 28 January 2013

Academic Editor: Rangnath Mishra

Copyright © 2013 Ming Li and Susumu Ikehara. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mesenchymal stem cells (MSCs) are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad tissue distribution. MSCs not only differentiate into types of cells of mesodermal lineage but also into endodermal and ectodermal lineages such as bone, fat, cartilage and cardiomyocytes, endothelial cells, lung epithelial cells, hepatocytes, neurons, and pancreatic islets. MSCs have been identified as an adherent, fibroblast-like population and can be isolated from different adult tissues, including bone marrow (BM), umbilical cord, skeletal muscle, and adipose tissue. MSCs secrete factors, including IL-6, M-CSF, IL-10, HGF, and PGE2, that promote tissue repair, stimulate proliferation and differentiation of endogenous tissue progenitors, and decrease inflammatory and immune reactions. In this paper, we focus on the role of BM-derived MSCs in organ repair.