Immunomodulatory Effects of Mesenchymal Stromal Cells Revisited in the Context of Inflammatory Cardiomyopathy
Table 1
Advantages and disadvantages of different cell administration routes for the treatment of inflammatory cardiomyopathy. As long as no studies are performed directly comparing the effectiveness of intravenous versus endocardial and intracoronary application in inflammatory cardiomyopathy, one cannot conclude that extracardiac targeting of MSCs is superior to high cardiac engraftment.
Application
Advantages
Disadvantages
Intravenous
Noninvasiveness Ability to perform reinjections [186] Homing to the site of injury and inflammation [181, 182] Extracardiac targeting [155] Systemic immunomodulatory effects [86, 127]
