Comparing the Gene Expression Profile of Stromal Cells from Human Cord Blood and Bone Marrow: Lack of the Typical “Bone” Signature in Cord Blood Cells

Table 1

Osteogenesis-related genes expressed uniquely in USSC, CBSC, or BMSC. After Venn diagram analyses (Figure 1(a)), the genes expressed uniquely in one cell population (USSC: 304, CBSC: 251, and BMSC: 375) were assigned to gene ontology (GO) terms using the “Functional Annotation Cluster Tool” provided by DAVID Bioinformatics Resources (http://david.abcc.ncifcrf.gov/). Only those GO terms associated with “bone formation” are presented.

AMBN: ameloblastin (enamel matrix protein); BCL2: B-cell CLL/lymphoma 2; CADM1: cell adhesion molecule 1; CHRDL2: chordin-like 2; COL12A1/14A1: collagen type XII alpha 1/type XIV alpha 1; FGF9: fibroblast growth factor 9; HOXC8/D10: homeobox C8/D10; IGF1: insulin-like growth factor 1; IGFBP5: insulin-like growth factor binding protein 5; MMP13: matrix metalloproteinase 13; NRCAM: neuronal cell adhesion molecule; PCDHB14/16: protocadherin beta 14/16; SPP1: secreted phosphoprotein 1 (Osteopontin); TDGF1: teratocarcinoma-derived growth factor 1; TFAP2A: transcription factor AP-2 alpha; TNFRSF11A: tumor necrosis factor receptor superfamily, member 11a.