Aldehyded Dextran and ε-Poly(L-lysine) Hydrogel as Nonviral Gene Carrier

Figure 1

The chemical structure and cross-linking of the new biodegradable hydrogel composed of aldehyded dextran/PLL and plasmid DNA. After the mixture of the solution, gel formation proceeds on the basis of Schiff base formation. Plasmid DNA interacts with PLL by electrostatic interactions between positively charged amine of the PLL and negatively charged phosphate groups of the plasmid DNA.