Emerging Therapeutic Strategies for Targeting Chronic Myeloid Leukemia Stem Cells

Figure 5

Alternative signaling pathways for overcoming resistance of CML Stem Cells against tyrosine kinase inhibitors. Sonic hedgehog (Shh), Indian hedgehog (Ihh), Desert hedgehog (Dhh), Smoothened (Smo), STAT5 (signal transducer and activator of transcription), retroinverso BCL6 peptide inhibitor (RI-BPI), chloroquine (CQ), hydroxychloroquine (HCQ), Sirtuin 1 (SIRT1), tenovin-6 (TV-6), Arachidonate 5-lipoxygenase (Alox5), stearoyl-CoA desaturase 1 (Scd1), promyelocytic leukemia protein (PML), arsenic trioxide (As₂O₃), and Interferon alpha (IFN).