Efficacy of Topical Mesenchymal Stem Cell Therapy in the Treatment of Experimental Dry Eye Syndrome Model
Figure 1
Ocular surface evaluation tests (Schirmer score, break-up time, fluorescein staining, and Rose Bengal staining) and corneal inflammatory index scoring test scores of groups. A marked increase in aqueous tear volume was observed in MSCs-treated rats, while aqueous tear volume decreased in PBS-treated controls after one week of therapy. The mean BUT score increased in MSCs-treated rats, while the score decreased in the PBS-treated group after one week of therapy. The mean Rose Bengal score decreased in MSCs-treated rats, while scores increased in PBS-treated controls. The mean fluorescein score decreased in MSCs-treated rats, while the score increased in PBS-treated controls after one week of therapy. The mean inflammation index scores decreased in MSC-treated rats, while scores increased in PBS-treated controls after one week of therapy. () within PBS-treated group tear volume and break-up time levels were slightly decreased and Rose Bengal score, the mean fluorescein score, and the mean inflammation index scores were slightly increased with no significant difference () and this might be due to sustained effect of 0.2% BAC or toxicity of diagnostic dyes and repeated manipulations.
