Migration, Proliferation, and Differentiation of Cord Blood Mesenchymal Stromal Cells Treated with Histone Deacetylase Inhibitor Valproic Acid

<table>VPA enhances migration of CB MSC towards a low SDF-1 gradient which is inhibited by CXCR4 and CXCR7 antagonists. CB-derived MSC were preincubated with or without 5 mM VPA for 3 h and allowed to migrate across Matrigel towards a low (20 ng/mL) or high (100 ng/mL) SDF-1 gradient. Cells were also incubated with CXCR4 antagonist AMD3100, CXCR7 antagonist CCX733, or the inactive CXCR7 antagonist CCX226. The data are based on two independent experiments; <svg height="11.85" id="M9" style="vertical-align:-1.29163pt" version="1.1" viewbox="0 0 66.875 11.85" width="66.875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> indicates statistically significant difference.</table>

Stem Cells International

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Figure 2

Figure 2: Migration, Proliferation, and Differentiation of Cord Blood Mesenchymal Stromal Cells Treated with Histone Deacetylase Inhibitor Valproic Acid 

Figure 2 | Migration, Proliferation, and Differentiation of Cord Blood Mesenchymal Stromal Cells Treated with Histone Deacetylase Inhibitor Valproic Acid 