Cell Therapy Augments Functional Recovery Subsequent to Spinal Cord Injury under Experimental Conditions

Table 2

Preclinical spinal cord injury trials using mesenchymal stromal cells (MSCs).

Transplanted cell type	SCI model	Neuronal regeneration	Functional recovery	Inflammation repression	Reference
r-BMMSCs	Rat, compression/contusion	Partial	Yes	Yes	[35–42]
m-BMMSCs	Mice, T9, compression	Partial	Yes	—	[43]
h-BMMSCs	Rat, T8-T9, complete transection	Yes	Yes	Yes	[44, 45]
h-UCMSCs	Dog, L2-3, compression	Yes	Yes	—	[46]
r-BMMSCs-NPCs	Rat, T8-T9, contusion/compression	Yes	Yes	—	[47, 48]
Canine-aMSCs-NPCs	Dogs, L2-3, compression	Yes	Yes	Yes	[49]
h-BMMSCs-NPCs	Rats, T9, contusion	Yes	Yes	—	[50]
r-BMMSCs-bFGF	Rats, T9, contusion	Yes	Yes	—	[51]
r-BMMSCs-NT3	Rats, T9, ethidium bromide induced demyelination	Yes	Yes	—	[52]
r-BMMSCs-NT3	Rats, T9, contusion	Yes	Yes	—	[53]
h-BMMSCs-HGF	Rats, C4, hemisection	Yes	Yes	Yes	[54]
h-BMMSCs-BDNF	Rats, T9, transection	Yes	Yes	—	[55]
r-BMMSCs-GDNF	Rats, T9, contusion	Partial	—	—	[56]
r-BMMSCs-MNTS1	Rats, T8, contusion	Yes	Yes	Yes	[57]
r-BMMSCs-TrkC	Rats, T10, complete transection	Yes	Yes	—	[58]

Rat bone marrow MSCs (rBMMSCs); human umbilical cord MSCs (hUCMSCs); basic fibroblast growth factors (bFGF); neurotrophin 3 (NT3); hepatocyte growth factor (HGF); brain derived neurotrophic factor (BDNF); glial cell line derived neurotrophic factor (GDNF).