Acute Lymphoblastic Leukemia Cells Inhibit the Differentiation of Bone Mesenchymal Stem Cells into Osteoblasts In Vitro by Activating Notch Signaling

<div>No toxic and apoptotic effect on BMSCs in the Jagged1 treatment. (a) The presence of both death and apoptotic BMSCs has been investigated by flow cytometry after 3 days in the presence and absence of recombinant Notch ligand Jagged1 or anti-Jagged1 neutralizing Ab. (b) The viability of BMSCs in the Jagged1 treatment using a cytotoxic assay after 14 days.</div>

Stem Cells International

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Figure 5

Figure 5: Acute Lymphoblastic Leukemia Cells Inhibit the Differentiation of Bone Mesenchymal Stem Cells into Osteoblasts In Vitro by Activating Notch Signaling 

Figure 5 | Acute Lymphoblastic Leukemia Cells Inhibit the Differentiation of Bone Mesenchymal Stem Cells into Osteoblasts In Vitro by Activating Notch Signaling 