Applications of Induced Pluripotent Stem Cells in Studying the Neurodegenerative Diseases

Table 2

Associated genes in patients with neurodegenerative diseases.

Disease types	Genes	References
Alzheimer’s disease	APP, PS1, PS2, APOE	[40–42]
Parkinson’s disease	GBA, LRRK2, PARK2, PARK7, PINK1, SNCA, UCHL1, MAPT	[43–45]
Amyotrophic lateral sclerosis	SOD1, FUS, TDP-43, C9ORF72	[46–48]
Spinal muscular atrophy	SMN1, SMN2	[49, 50]
Down syndrome	Trisomy 21	[50, 51]
Huntington disease	HTT (CAG-type repetitive DNA sequences)	[52, 53]