Satellite Cells CD44 Positive Drive Muscle Regeneration in Osteoarthritis Patients

Figure 2

Protein expression analysis. Immunostaining for BMP-2, myostatin, and CD44 was evaluated by counting the number of positive fibers/cells on 25-high power field (HPF), whereas western blot for BMP-2 was evaluated by lines densitometry. (a) Notably, we found that OA muscle biopsies showed a significantly higher number of BMP-2-positive fibers () as compared with muscle of OP patients () (). (b) Western blot lines show a higher expression of BMP-2 in OA patients compared to OP group. (c) The number of myostatin positive fibers in OP patients was significantly higher compared to OA group (). (d) CD44 expression shows a significantly different rate of CD44 positive cells in OA group as compared with OP ().

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