|
| Polymers type | Fabrication method | Cellular type | In vitro or
in vivo | Stimulations | Time | Results | References |
|
| PGA bonded PLGA | Lyophilization | Allogeneic rabbit meniscal chondrocytes | In vivo (rabbit) | None | 36 weeks | Proteoglycan types I and II collagen in neomenisci
Differences in collagen content and aggregate modulus in comparison with native meniscus | Kang et al. (2006) [50] |
|
| Pu | Solvent leaching | None | In vivo (male Wistar rats back) | None | 24 weeks | Unorganized collagen deposition in isotropic scaffolds
Collagen alignment in anisotropic scaffolds |
De Mulder et al. (2013) [51] |
|
| PLDLA/PCL-T | Solvent casting and particulate leaching | Rabbit meniscus fibrochondrocytes | In vivo (rabbit) | None | 24 weeks | Without apparent rejection, infection, or chronic inflammatory response
Mature collagen in seeded cells scaffolds | Esposito et al. (2013) [52] |
|
| PEO loaded collagenase | Electrospinning | None | In vitro | None | 4 weeks | Improved repair by promoting cell migration, proliferation, and matrix deposition | Qu et al. (2013) [53] |
|
| PCL | Electrospinning | Juvenile bovine MSCs | In vitro | Collagenase and ChABC | 120 days | Collagen dominated tensile response, GAG dominated compressive properties, and GAG removal result in significant stiffening in tension | Nerurkar et al. (2011) [54] |
|
| PCL mixed PEO | Electrospinning with rotating mandrel | Juvenile meniscus fibrochondrocytes | In vitro | Various porosity and preseeding | 8 weeks | Highly porous scaffolds integrate better with a native tissue and mature, preseeding improved
integration with the native tissue |
Ionescu and Mauck (2013) [55] |
|
| HYAFF/PCL | Lamination
technique | Autologous chondrocytes | In vivo (sheep) | Transosseous
horns fixation | 4 months | Better implant appearance was in without fixation group; significant cartilaginous tissue formation and lower joint degeneration was in cell-seeded group | Kon et al. (2008) [56] |
|
| HYAFF/PCL | Lamination
technique | Autologous chondrocytes | In vivo (sheep) | None | 12 months | Avascular cartilaginous formation was more frequent in cell-seeded constructs; OA was less in cell-seeded group than in meniscectomy group | Kon et al. (2012) [57] |
|
| Actifit | — | None | In vivo (sheep) | None | 12 months | Promoting tissue ingrowth into porous scaffolds
Friction coefficient of scaffolds decreasing to near native values | Galley et al. (2011) [58] |
|
| Actifit | — | None | Clinical cases (54 patients) | None | 24 months | Significant improvements of pain and function scores; scaffold is safe and effective in treating lateral meniscus defects | Bouyarmane et al. (2014) [59] |
|
| Actifit | — | None | Clinical cases
(18 patients) | None | 24 months | Scaffold with chronic segmental medial meniscus deficiency is not only a safe procedure but leads to good clinical results |
Schüttler et al. (2014) [60] |
|
| Actifit | — | None | Clinical cases
(18 patients) | None | 24 months | No deleterious effects on patients
Inducing and promoting meniscal regeneration by normal chondrocytes and fibrochondrocytes
Beneficial in decreasing the risk of progression to knee OA | Baynat et al. (2014) [61] |
|
