Modulation of Hyaluronan Synthesis by the Interaction between Mesenchymal Stem Cells and Osteoarthritic Chondrocytes

Figure 3

mRNA expression of hyaluronan enzymes by BM-MSCs and OA-chondrocytes. Relative mRNA expression of hyaluronan-related enzymes after 3 days (a) or 6 days (b) in monoculture. Bars represent the mean ± SEM of hyaluronan synthase- (HAS-) 1, HAS-2, and HAS-3 and hyaluronidase- (HYAL-) 2 and HYAL-3 mRNA expression. All fold changes were calculated relative to a calibrator sample. Statistical significance based on unpaired t-test was set according to the number of asterisks, as follows: , .

(a)

(b)