Exosomes Secreted from CXCR4 Overexpressing Mesenchymal Stem Cells Promote Cardioprotection via Akt Signaling Pathway following Myocardial Infarction

Figure 3

The effect of -derived exosomes on apoptosis. (a) TUNEL staining for CM apoptosis under hypoxic condition. CM labeled with cardiac specific antibody, sarcomeric α-actinin (red). Nuclei were labeled with DAPI (blue) and TUNEL positive nuclei (green). Original magnification ×200. (b) Quantitative data for the numbers of TUNEL positive nuclei in various experimental groups. All values expressed as mean ± SEM. versus ; for each group. CM + , CM treated with -derived exosomes; CM + , CM treated with -derived exosomes; CM + + LY, CM + -treated with LY294002 (a PI3K inhibitor); CM + + LY, CM + treated with LY294002; CM + , CM treated with -derived exosomes.

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