Bone Marrow-Derived Multipotent Stromal Cells Promote Myocardial Fibrosis and Reverse Remodeling of the Left Ventricle

Figure 4

The scar morphology and LV remodeling features related to the transplantation. (a) Transverse sections of the heart stained with picrosirius red. Large foci of postinfarction cardiosclerosis were found in all animals including the controls at p/t day 14 (i.e., at 44 days after the MI); panoramic shots were made at 25x magnification. (b) Transverse section of the heart before transplantation, 30 days after MI. (c) Fine structure of the scar, stained with picrosirius red, observed in normal and polarized light. The scar of the autologous transplantation specimen appears more organized and compact. (d) The diagrams show dynamics of the indices relevant to LVRR. The data are presented as mean ± SEM with asterisks indicating significant differences. Scale bars, 50 μm.

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