Reprogramming with Small Molecules instead of Exogenous Transcription Factors

Figure 1

Differentiation and reprogramming are influenced by various mechanisms. Small molecules used to generate iPSCs can be categorized as epigenetic modifiers, WNT signal modulators, cell senescence moderators, modulators of metabolism, and regulators of MET and cell death/senescence pathways. They can influence both differentiation and reprogramming (dedifferentiation).