Mesenchymal Stem/Stromal Cells Derived from Induced Pluripotent Stem Cells Support CD34^pos Hematopoietic Stem Cell Propagation and Suppress Inflammatory Reaction

Figure 4

Adipogenic, osteogenic, and chondrogenic differentiation potential of hiPSC-MSCs and BM-MSC (LM06). Oil Red-O staining for lipid formation, alizarin red staining of mineralized deposits, and alcian blue staining for chondrocyte pellet formed by the three iPSC-MSC-like cell lines. mRNA expression level of the relative expression of genes associated with adipogenesis , PPARα, and LPL, osteogenesis (osteocalcin and alkaline phosphatase), and chondrogenesis (collagen type II and aggrecan). The data represent the mean expression values normalized to the housekeeping gene GAPDH. : significance difference with BM-MSCs .