Study on the Dynamic Biological Characteristics of Sca-1⁺ Hematopoietic Stem and Progenitor Cell Senescence

Figure 7

Protein expression of , P53, , CyclinD1, P19, CDK2, CyclinE, and CDK4 in Sca-1⁺ HSPCs. (a) Result of western blot. A: Group A (3-4-week-old mice, 13–16 g in body weight), B: Group B (8-9-week-old mice, 20–25 g in body weight), C: Group C (6-month-old mice, 35–40 g in body weight), D: Group D (12-month-old mice, 39–43 g in body weight), and E: Group E (18-month-old mice, 37–45 g in body weight). (b) Ratio of protein to β-actin. (a–d) represent a significant difference of these columns ().

(a)

(b)