Periodontal Ligament Stem Cells: Current Status, Concerns, and Future Prospects

Figure 3

Biological safety during application of periodontal ligament stem cells. Donors must be free of viral infection to prevent cross infection between donor and recipient. Also, contamination by pathogenic microorganisms and adventitious agents during culture should be excluded. Next, the risk of tumor formation must be evaluated before PDLSC transplantation. Also, immunosuppressive ability should be tested to ensure the safety of allogeneic PDLSC transplantation. Finally, long-term follow-up of recipients is necessary to study the fate of PDLSCs and to minimize future risks after transplantation.