Dexamethasone Regulates EphA5, a Potential Inhibitory Factor with Osteogenic Capability of Human Bone Marrow Stromal Cells

Figure 5

Proposed mechanisms by which EphA5 inhibits hBMSC osteogenesis. Coexpression of EphA5 and ephrins regulates hBMSC osteogenesis. Repeating passaging upregulates EphA5 but not ephrins, which results in an excess of nonligated EphA5. An imbalance between receptor and ligand expression may compromise other Eph ligand-dependent differentiation processes and promote ligand-independent suppression in hBMSCs.