A Genomic Study of DNA Alteration Events Caused by Ionizing Radiation in Human Embryonic Stem Cells via Next-Generation Sequencing

Figure 3

Representative snapshots of Integrative Genomics Viewer (IGV, Broad Institute, Boston, MA) showing the aligned reads for the rare variants detected in samples exposed to 1 Gy of ionizing radiation. (a) At position chr4:55593481 in the KIT protooncogene of H1 cells. (b) At position chr5:112175620 in the tumor suppressor gene APC of H9 cells. (c) At position chr7:128846393 in the SMO oncogene of H9 cells. Each horizontal grey bar represents an individual read with the variant highlighted with vertical columns (A > G in panel (a), and T > G in panel (b), and T > A in panel (c)).

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