Whole-Genome Expression Analysis and Signal Pathway Screening of Synovium-Derived Mesenchymal Stromal Cells in Rheumatoid Arthritis

Table 5

GO analysis of RA SMSCs with different molecular functions related to differentially expressed genes.

GO ID	Term	Regulation	Number of genes	Percentage of total gene number	Fold enrichment	value
GO:0005488	Binding	Up	1331	42.70%	1.107406186
GO:0005515	Protein binding	Up	895	28.71%	1.259276446
GO:0003824	Catalytic activity	Up	645	20.69%	1.218132345
GO:0043167	Ion binding	Up	435	13.96%	1.110490713	0.004421943
GO:0043169	Cation binding	Up	433	13.89%	1.108515605	0.005140801
GO:0046872	Metal ion binding	Up	424	13.60%	1.097341066	0.011174111
GO:0016787	Hydrolase activity	Up	300	9.62%	1.291345373
GO:0000166	Nucleotide binding	Up	298	9.56%	1.314022658
GO:0017076	Purine nucleotide binding	Up	250	8.02%	1.329326120
GO:0032553	Ribonucleotide binding	Up	249	7.99%	1.332560002
GO:0005488	Binding	Down	548	32.03%	1.037520988	0.031108598
GO:0005515	Protein binding	Down	352	20.57%	1.127010990	0.001007060
GO:0042802	Identical protein binding	Down	45	2.63%	1.385306122	0.016715118
GO:0043565	Sequence-specific DNA binding	Down	41	2.40%	1.388762475	0.020934665
GO:0005198	Structural molecule activity	Down	40	2.34%	1.491048874	0.007638802
GO:0019955	Cytokine binding	Down	14	0.82%	2.778713450	0.000496933
GO:0008083	Growth factor activity	Down	13	0.76%	1.793577236	0.030091084
GO:0008022	Protein C-terminus binding	Down	12	0.70%	1.810133333	0.034106543
GO:0019838	Growth factor binding	Down	11	0.64%	2.262666667	0.009349359
GO:0015631	Tubulin binding	Down	11	0.64%	2.183274854	0.012057826