Whole-Genome Expression Analysis and Signal Pathway Screening of Synovium-Derived Mesenchymal Stromal Cells in Rheumatoid Arthritis

Table 6

KEGG pathway analysis results for RA SMSCs.

Pathway ID	Definition	Regulation	Selection counts	Gene names	value
hsa04010	MAPK signaling pathway	Up	47	ARRB1, ATF2, BDNF, CACNA1C, CASP3, CHUK, CRK, DUSP10, DUSP3, DUSP5, EGFR, FGF10, FGF7, FGFR1, FGFR2, GNG12, HSPA2, HSPA6, HSPA8, IL1R1, JUN, MAP2K4, MAP3K12, MAP3K2, MAP3K4, MAP3K5, MAP3K7, MAP3K8, MAP4K3, MAP4K4, MAPK10, MAX, NF1, PDGFRA, PLA2G4A, PPM1A, PPP3CB, RAPGEF2, RPS6KA3, RRAS2, SOS1, SOS2, STK3, TGFB3, TGFBR1, TGFBR2, and ZAK	0.002378379
hsa05323	Rheumatoid arthritis	Up	18	ANGPT1, ATP6V0A1, ATP6V1A, ATP6V1C2, ATP6V1G1, CCL2, CTSK, CXCL1, CXCL12, CXCL5, CXCL6, HLA-DQA1, ICAM1, IL6, JUN, MMP1, MMP3, and TGFB3	0.018097090
hsa04115	p53 signaling pathway	Down	13	BBC3, CASP9, CCNB1, CCNB2, GADD45B, GTSE1, IGF1, IGFBP3, RPRM, RRM2, SERPINE1, SESN2, and SESN3	0.000017539