Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease

Table 1

Examples of NPs-based gene delivery in stem cells.

Stem cells	Species	Cell source	Type of NPs	NPs vectors	Internalization	In vivo test	Disease model	References
MSCs	Mouse	Bone marrow	Polymer	Hyperbranched poly(amidoamine)	Not reported	Yes	MI	[32]
SkMs	Human	Skeletal muscle	Liposome	Cholesterol-DOTAP liposome	Not reported	Yes	MI	[31]
MSCs	Rat	Bone marrow	Inorganics	Calcium phosphate	Not reported	No	—	[41]
MSCs	Human	Bone marrow	Blended	PEI-coated multiple QD bundled NPs	96.71% of NPs internalization after 6 h (QD655)	No	—	[45]
MSCs	Rat	Bone marrow	Blended	Cationic lipids (lysinylated, histidylated, or arginylated cholesterol)-coated PEI	99.6% of NPs internalization after 4 h (lysinylated cholesterol-coated PEI)	No	—	[46]

MI, myocardial infarction; MSCs, mesenchymal stem cells; SkMs, skeletal myoblasts.