Lovastatin Decreases the Expression of CD133 and Influences the Differentiation Potential of Human Embryonic Stem Cells

Figure 5

Expression of differentiation markers in hES cells during differentiation into ectodermal, mesodermal, or endodermal lineages after treatment with lovastatin. (a) Expression of the ectodermal lineage markers SOX1 and OTX2 in comparison to the expression of OCT4 and SOX2. (b) Expression of the endodermal lineage markers GATA4, FOXA2, and SOX17 in comparison to OCT4 expression. (c) Expression of the mesodermal lineage markers brachyury and HAND1 and in comparison to the expression of OCT4. (d) The mean number of cells ± SD () expressing ectodermal (EC), mesodermal (ME), or endodermal (EN) lineage markers.

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