Review Article
Metaboloepigenetic Regulation of Pluripotent Stem Cells
Table 1
Summary of metabolites linked with epigenetic modifications in pluripotent stem cells.
| Metabolite | Epigenetic intermediate | Metabolic pathway | Epigenetic target | References |
| Threonine | SAM (via glycine) | Folate/SAM cycles | H3K4me3 | [60–62] | Acetyl-CoA |
| Methionine | SAM | SAM cycle | H3K4me3 | [64] |
| Glutamine | αKG | TCA | H3K9me3 |
[65] | H3K27me3 | H3K26m3 | H4K20me3 |
| L-Proline | TBD | TBD | MRT |
[74] | H3K9me | H3K36me |
| Glucose | Acetyl-CoA | (glycolysis-derived) | H3K9/K27ac |
[76] | (from citrate) | Pyruvate oxidation |
| TBD | TBD | O-GlcNAc | me/TETs | [83] |
| TBD | NAD+ | TBD | ac/sirtuins | — |
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