Genetic Background of Immune Complications after Allogeneic Hematopoietic Stem Cell Transplantation in Children

Table 4

Summary of the pathway analysis for the differentially expressed genes from TOP 250 database between the post-HSCT and pre-HSCT group.

Fold change; Number of exported genes	Name of pathway map	Number of pathway maps	Published by	Participating genes (%)
Whole list; 250; Underexpressed	Ribosome	hsa03010	KEGG_PATHWAY	26.5
	Porphyrin and chlorophyll metabolism	hsa00860
	Primary immunodeficiency	hsa05340
	Hematopoietic cell lineage	hsa05213
	Aldosterone-regulated sodium reabsorption	hsa04960
	Hemoglobin Chaperone	h_ahsp	BIOCARTA	10.3
	Th1/Th2 Differentiation	h_th1th2
	3′-UTR-mediated translational regulation	REACT_1762	REACTOME_PATHWAY	17.6
	Influenza infection	REACT_6167
	Metabolism of proteins	REACT_17015
	Metabolism of porphyrins	REACT_9431
	Gene expression	REACT_71
Whole list; 250; Overexpressed	Type I diabetes mellitus	hsa04940	KEGG_PATHWAY	20.8
	Allograft rejection	hsa05330
	Graft-versus-host disease	hsa05332
	Autoimmune thyroid disease	hsa05320
	Viral myocarditis	hsa05416
	Hematopoietic cell lineage	hsa05213
	Antigen processing and presentation	hsa04612
	Natural killer-cell mediated cytotoxicity	hsa04650
	B-cell receptor signaling pathway	hsa04662
	Primary immunodeficiency	hsa05340
	Neuroactive ligand-receptor interaction	hsa04080
	Cytokine-cytokine receptor interaction	hsa04060
	Signaling of immune system	REACT_6900	REACTOME_PATHWAY	15.3
	CTCF	h_ctcf	BIOCARTA	8.8
	B-cell receptor complex	h_bcr
	Inflammation mediated by chemokine and cytokine pathway	P0003	PANTHER_PATHWAY	12
	B-cell activation	P00010
≥1.5; 44	Hematopoietic cell lineage	hsa05320	KEGG_PATHWAY	19.5
	Epithelial cell signaling in Helicobacter pylori infection	hsa05120
	B-cell activation	P00010	PANTHER_PATHWAY	12.2
≤−1.5; 80	Porphyrin and chlorophyll metabolism	hsa00860	KEGG_PATHWAY	32.3
	Hemoglobin Chaperone	h_ahsp	BIOCARTA	16.1
	Heme biosynthesis	P02976	PANTHER_PATHWAY	14.5
	Metabolism of porphyrins	REACT_9431	REACTOME_PATHWAY	21