Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers

Figure 5

Electrical characterization of IMR hiPS-cardiomyocytes (CMs). (a-b) Activation maps showing the propagation of contraction on day 6. The white arrow marks the fiber orientation and the green arrow marks the delay area. (c) Field potentials (FPs) of CMs cultured on the two types of substrates at day 6. (d) Amplitude of FP at different culture times (means ± s.e., , ). (e) The ratio of the channels recording the T-wave (means ± s.e., , , ). (f) cQT intervals recorded from CMs at different culture times (means ± s.e., ). (g) CM beating rate at different culture times (means ± s.e., ). (h) Conduction velocity of spontaneous contraction propagation at different culture times (means ± s.e., , ).

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