XPC Promotes Pluripotency of Human Dental Pulp Cells through Regulation of Oct-4/Sox2/c-Myc

Figure 3

Effect of XPC on cell proliferation and apoptosis and cell cycle and senescence of DPCs with in vitro culture. CCK8 revealed that cell proliferation of transfected DPCs at both P3 and P7 was significantly enhanced (b1, ). The result of FACS (a1–a6) demonstrated that the cell number of transfected DPCs at P3 and P7 in G0/G1 was significantly downregulated compared with the vector groups; DPCs were arrested in G2/M and S phase. The percentage of PI = (S + G2/M) value (b3, ) and telomerase activity (b4, ) of transfected DPCs at both P3 and P7 was significantly upregulated, albeit the apoptosis rate was significantly downregulated (b2, ).