Theoretical and Practical Issues That Are Relevant When Scaling Up hMSC Microcarrier Production Processes

<div>Comparison of fluid flow in the BIOSTAT CultiBag RM 2L at three different working volumes (0.5 L, 1.0 L, and 1.5 L). (a) Contour plots of CFD-predicted fluid flow patterns and fluid flow velocities for three different working volumes. The fluid flow patterns and the fluid flow velocities are shown for 25 rpm and 10°. (b) Comparison of volume-weighted mean fluid flow velocities over one period.</div>

Stem Cells International

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Figure 5

Figure 5: Theoretical and Practical Issues That Are Relevant When Scaling Up hMSC Microcarrier Production Processes 