Theoretical and Practical Issues That Are Relevant When Scaling Up hMSC Microcarrier Production Processes

Table 2

Specific metabolic consumption and production rates.

[rpm]	[pmol cell^−1 d^−1]	[pmol cell^−1 d^−1]	[mmol mmol^−1]	[pmol cell^−1 d^−1]	[mmol mmol^−1]
25	−1.86 ± 0.01	4.31 ± 0.03	2.87 ± 0.01	0.259 ± 0.004	2.65 ± 0.41
43	−2.30 ± 0.20	4.39 ± 0.30	1.94 ± 0.30	0.252 ± 0.003	2.66 ± 0.29
49	−1.58 ± 0.11	2.43 ± 0.17	1.55 ± 0.11	0.090 ± 0.001	2.46 ± 0.46
63	−1.08 ± 0.23	2.92 ± 1.04	2.51 ± 0.39	0.191 ± 0.052	2.36 ± 0.49
90	−4.09 ± 0.52	7.78 ± 1.39	1.89 ± 0.10	0.596 ± 0.133	2.43 ± 0.11
120	−5.07 ± 0.19	8.82 ± 0.11	1.74 ± 0.04	0.878 ± 0.085	2.57 ± 0.05

: specific glucose consumption rate; : specific lactate production rate; : specific ammonia production rate; : specific lactate yield per unit glucose; : specific ammonia yield per unit glutamine. ().