Theoretical and Practical Issues That Are Relevant When Scaling Up hMSC Microcarrier Production Processes

Table 3

Summary of predicted shear stress levels and specific power inputs in the BIOSTAT CultiBag RM 2L.

Working volume [L]	Rocking angle [°]	Rocking rate [rpm]	[W m^−3]	MLSS [10^−3 N m^−2]
0.5	4	26	20.61/40.66	5.83/664
0.5	6	22	32.52/53.55	5.44/509
0.5	6	35	156.01/262.60	5.78/597
0.5	8	18	47.71/85.79	29.61/704
0.5	10	14	93.40/149.73	20.61/885
0.5	10	25	144.10/259.76	26.40/3162
1.0	4	29	34.40/65.33	4.91/916
1.0	6	25	53.70/98.16	4.75/1194
1.0	8	20	32.14/53.35	1.09/289
1.0	10	15	81.10/123.77	5.68/1012
1.0	10	25	118.32/203.76	10.80/4042
1.5	4	31	8.92/17.69	0.49/214
1.5	6	27	17.96/32.45	0.60/256
1.5	8	22	26.56/50.04	0.74/279
1.5	10	16	68.85/105.28	3.15/909
1.5	10	25	95.02/155.46	4.86/2959

: mean and maximum values of specific power input. MLSS: maximum values of local volume-weighted mean and maximum shear stresses over one period.