Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival

Figure 3

Proliferative and differentiation potential of MSC engineering. An improvement in the proliferative hallmarks of MSCs could be accomplished by the stimulation of proproliferation genes regulated by Sox2 and Oct4 transcription factors. Furthermore, senescence-related genes could be silenced (i.e., lipocalin-2 production), or oxidative stress resistance might be enhanced (i.e., PSMB5).