Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival

Figure 4

MSC prosurvival engineering. Prosurvival strategies primarily target the apoptosis process by downregulation of the elements involved in the apoptotic cascade (i.e., caspase 8 inhibition by miR-155). Other approaches involve the induction of prosurvival genes (i.e., HIF-1α), while still others ensure protection from fluid-stress or complement-mediated lysis.