Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function

Figure 3

Quiescent HSC and proliferating progenitors respond differently to DNA damage (radiation). HSC show a higher expression level of p53 and p21 and they activate the error-prone repair pathway compared to faster cycling progenitors. They show a reduced DDR, NER, and HR response. (NHEJ: nonhomologous end joining; DDR: DNA damage response; NER: nucleotide excision repair; and HR: homologous recombination).