Allogeneic Mesenchymal Stem Cell Treatment Induces Specific Alloantibodies in Horses

Figure 3

Anti-BSA antibodies in horse prior to and after MSC administration. Sera from 18 horses were available for anti-BSA antibodies determination via ELISA. Each dot represents serum from a horse prior to MSC administration and sera from the same horse after MSC administration. Before and after dots from each horse are connected with a line. Horses with no measurable anti-BSA antibodies served as negative controls and anti-BSA titer is presented as fold increase over these negative controls. While 16 of the 18 horses (89%) had positive anti-BSA antibodies titer prior to MSC administration, none of the horses developed higher antibodies titer after MSC administration. Moreover, the 2 horses that did not have measurable anti-BSA antibodies prior to MSC administration did not seroconvert after MSC administration.