Cryopreservation of Bone Marrow Mononuclear Cells Alters Their Viability and Subpopulation Composition but Not Their Treatment Effects in a Rodent Stroke Model

Figure 2

Line diagrams illustrating the neurofunctional improvement in mice treated with MNCs IV at 24 hours after stroke. Animals were assigned to 3 treatment groups: saline (), fresh MNCs (), or frozen MNCs (). All animals were evaluated on the corner test (a), where smaller value in -axis meant more severe deficits and ladder rung tests (b), where larger value in axis meant more severe deficits, up to 28 days after stroke. Data are mean ± SD; : , frozen MNCs versus saline; : , fresh MNCs versus saline.

(a)

(b)