p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose γ-Irradiation

Figure 6

Impact of p53 status on senescence induction and number of DNA repair foci. (a) Graph shows percentage of p53−/− mMSCs undergoing senescence in hypoxic and normoxic conditions after exposure to γ-irradiation (sham-irradiated = 0 Gy, 3 biological replicates), radiation dose on logarithmic scale. (b) Quantification of p-γH2AX foci in 50 p53−/− mMSC nuclei depicted as mean values ± standard error of the mean (3 biological replicates).

(a)

(b)