Endothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and Angiogenesis

<div>A model explains the crucial role of hypoxia-induced Twist1 to mediate different important processes of tumor progression including EMT, metastasis, cancer stemness, and endothelial differentiation through regulation of BMI1 or Jagged1/Notch-KLF4 axis.</div>

Stem Cells International

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Figure 2: Endothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and Angiogenesis 

Figure 2 | Endothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and Angiogenesis 