Adiponectin Isoforms and Leptin Impact on Rheumatoid Adipose Mesenchymal Stem Cells Function

Figure 1

Adipokines effects on secretory activity of ASCs derived from rheumatoid infrapatellar fat pad. Unstimulated (Ctrl) or stimulated with 10 ng/mL leptin (Lep), 10 μg/mL of LMW adiponectin, or 10 μg/mL of HMW/MMW adiponectin ASCs from RA patients were cultured for 24 h. Concentrations of select factors were measured in supernatants collected from ASCs cultures using specific ELISA tests (n = 14–18). Asterisks () indicate statistically significant differences versus Ctrl; hash marks (#) indicate statistically significant differences between indicated data. , , and .