The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming

Figure 3

The ubiquitination and deubiquitination processes. A ubiquitin E3 ligase enzyme catalyzes the transfer of ubiquitin to lysine residue on the targeted protein and channels the protein to the 26S proteasome for protein degradation. Another class of enzyme, called deubiquitinating enzymes, that is able to reverse ubiquitin conjugation from protein substrates, thereby preventing proteolysis.