The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming

Figure 5

Schematic representation of the roles of E3 ligases and deubiquitinating enzymes in regulating stem cell differentiation and stem cell maintenance. Ubiquitination of core stem cell transcription factors by E3 ligases mediates stem cell differentiation. Deubiquitination of the core stem cell transcription factors by DUBs mediates stem cell maintenance.