Spontaneous Physical Activity Downregulates Pax7 in Cancer Cachexia

Figure 1

C26-bearing mice show reduced muscle regeneration after acute injury. Panel (a) depicts representative details of H&E-stained muscle cross-cryosections of the lesion sites from both control and C26-bearing mice. Bar = 100 μm. (b) Morphometric analysis of regenerating fiber size from (a). Histograms show the distribution of the regenerating fiber cross-sectional area in different size classes 6 days after muscle damage (control = black bars; C26-bearing mice = gray bars). Numbers represent the median value. (c) Number of fibers with centrally located nuclei observed in the lesion site of the tibialis from both C26-bearing and control mice after acute damage. The total number of regenerating fibers was monitored at 6, 8, and 10 days after freeze-injury (control = black dots; C26-bearing mice = white dots).

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