Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity

Figure 4

(a–c) Number of large and small lipid droplets from Oil Red O stained MSCs with 5 mg/dL uric acid with or without CoPP, in the presence or absence of SnMP; magnifications: 40x (). A representative section for each group is shown. Values represent means ± SEM of five independent treatments. versus CTR; versus UA; and versus UA + CoPP. (d) Real-time PCR of Mest. (e) and (d) Real-time PCR of FAS expression in MSCs treated with uric acid with or without CoPP, in the presence or absence of SnMP. Values represent means ± SEM of five independent treatments. versus CTR; versus UA; and versus UA + CoPP.

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