Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity

Figure 7

(a) Adipogenesis as shown by Oil Red O staining in MSCs treated with 500 μM fructose with or without CoPP and with or without allopurinol, a known inhibitor of XO. A representative section for each group is shown; versus CTR; versus Fr. (b) Adipogenesis as shown by Oil Red O staining in MSCs treated with 5 mg/dL uric acid with or without CoPP and with or without apocynin, a known inhibitor of NADPH oxidase, magnifications: 40x (). A representative section for each group is shown. Values represent means ± SEM of five independent treatments. versus CTR; versus UA.

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