Stem Cell Therapy for Treatment of Ocular Disorders

Figure 1

Crucial biomolecules expression in an embryonic mouse at 9.5 days. The neural ectoderm (NE) bulges as optic vesicle (OV) to reach the surface ectoderm (SE) on both sides. The SE became thicker upon the contact of NE to become the lens placode. Except in the lens placode region, the NE and SE are separated by the EOM. In the NE, the presumptive RPE, neural retina, and optic tract are colored red, green, and yellow, respectively. The lens placode is colored blue. The TF reciprocally act to regulate eye development. EOM, extraocular mesenchyme; RPE, retinal pigmented epithelium; NR, neural retina; TF, transcription factor. Copyright 2012. Modified with permission from Cold Spring Harbor Laboratory Press [26].