Review Article
The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells
Table 2
The regulatory functions of miRNAs on PCSCs properties.
| Upregulation of onco-miRNAs | Downregulation of tumor suppressor miRNAs | Potential targets | Biological PCSCs behavior | Reference |
| miR-21 | | PI3K/AKT | Proliferation and chemoresistance | [37–39] | | miR-200a/c | n-cadherin, ZEB 1 | EMT, stemness maintenance | [40–42] | | miR-34 | BCL2 | Self-renewal | [43, 44] | | miR-143/miR-145 | Kras | Cancer cell growth | [45] | | miR-1246 | CCNG2 | Chemoresistance and stemness | [46] |
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